The busiest time of the year has come. You may juggle holiday decorations, shopping, and childcare while working from home. But if you are traveling and working remotely for the holidays, you’ll need to plan and take extra precautions to avoid rookie blunders.
Furthermore, working remotely may be a learning curve if you’ve never worked remotely before. These tips and suggestions will serve as helpful reminders for newcomers and veterans during the holiday rush.
Table of Contents
Remote Work Holiday Travel Tips
1. Before you go, make sure your devices are fully charged.
During the holidays, there are only a few outlets in airports and on trains, and you may be too far away from one to charge your phone or laptop comfortably.
2. Bring Your On-the-go Chargers (that are charged).
If you want to be productive on a plane or train excursion, even with trusted devices, your battery may lose a full charge depending on the length of your trip. To be prepared, bring backups or powerbanks, and keep your phone, laptop, Kindle, iPad, or other device loaded until you arrive.
3. Save files to your computer for offline use.
Although most planes, trains, and buses now have WiFi, some still do not. When they do have WiFi, it’s usually spotty or slow, so downloading presentations or files to work on offline can be more productive than working in a WiFi-only environment.
4. Take a MiFi device with you.
While waiting in the airport, WiFi can be spotty and expensive for faster service. Bring a MiFi device with you so you can create a personal hotspot wherever you go. This way, you’ll only have to pay for data for as long as needed.
5. Organize your affairs.
If you plan to be gone for an extended period, it’s a must to ensure you have everything you’ll need from an administrative standpoint and get everything in order at home.
Make sure you have multiple debit cards if one is lost or broken so you don’t end up in a foreign country without access to cash. Due to cancellation policies, a credit card is also helpful in booking flights and housing.
Another essential thing to have is insurance.
Long-term travel insurance can be prohibitively expensive, so consider getting international health insurance instead. While this does not cover things like stolen property or canceled flights, ensuring you have access to healthcare in the event of an accident is far more critical.
6. Meet with other digital nomads to find out where they’re going.
When you’re traveling, most of the people you meet will most likely come and go quickly because they’re on a short-term trip or vacation. Finding digital nomad hotspots, such as co-working spaces, is a good idea, as it allows you to form longer-term relationships and a sense of community with other remote workers who aren’t pressed for time.
7. Create a healthy work routine.
When you arrive at a new destination, it’s easy to get caught up in all the exciting new things to see and do, so establishing a healthy work routine — and sticking to it — is critical to ensuring you maintain a healthy balance between travel and work. Even if your job does not require it, maintaining a regular workweek and weekend schedule is one way to achieve this.
You Might Also Be Interested: The Ultimate Guide to Spain’s Digital Nomad Visa: Live, Work, and Explore in Sunny Spain
Tips for Working Remotely Over the Holiday
1. Discover your flexibility.
Working remotely usually entails a certain amount of schedule freedom. Take advantage of not having to go to work and hunt for extra time during the day to complete your tasks.
You can choose to get up an hour or so before the kids to prepare your day, prioritize your to-dos, and begin working on one major project. You’ll be able to attend your child’s school holiday party while also meeting your deadlines.
2. Choose a location that is free of distractions.
Sitting in the center of the commotion won’t help you get work done while you’re at home with your family or friends. You may think you’re working, but if you’d only chosen a peaceful spot, you could have completed your assignment in a fourth of the time, allowing you to spend more time with your loved ones.
3. Ensure you have most of the tools needed.
Don’t forget to bring your laptop charger, headphones, wireless mouse, video conferencing camera, and necessary files. If you travel great distances, ignoring something could mean being without it for 2-4 weeks, so double-check everything before you depart and plan.
4. Be sure your calendar is up to date with your schedule.
When some teammates are online the week of Christmas but not the week of New Year’s Day, when some are online and offline every other day, and when others are not available at all (maybe they’ve been saving their vacation days for a nice, long getaway), team planning can get problematic. Everyone has the right to their schedule, but it’s crucial to communicate when you’ll be accessible and unavailable to your team, clients, or anybody else with whom you operate.
5. Create suitable Slack/email away messages.
Ensure that your team is aware of your activities throughout the day. Remember that while you’re working remotely at different hours than usual, your coworkers may not be taking time off and may be working at full pace without having modified their hours.
When your Slack profile shows you as accessible one minute and gone the next, teammates may become annoyed trying to track you down. Let folks know where you are at any given moment using your instant messaging and email vacation responder.
It’s OK to be wholly and away disconnected during the holidays. Just remember that if you claim you’re working, you must be active and accountable.
Read More: Comprehensive Guide to Remote Work
6. Seek Assistance.
If the pressures of the season are becoming too much for you, seek Assistance. Friends and family can assist you in watching children while you work.
Older children can also help with specific projects. Elementary school-aged children, for example, can assist in sorting mail, filing papers, and even shredding documents. Your high schooler can do post office runs and other errands for you, making your workday run more smoothly.
So, take a look at your job responsibilities and see which ones you can delegate during this time to improve your work-life balance.
7. Always remember to take breaks.
Some people who work from home become so engrossed in their work that they forget to take a lunch break or even stretch their legs. With no cues from coworkers leaving for a holiday, it’s easy to see how this could happen. However, taking breaks from the computer from time to time is necessary to recharge, refuel, and refocus.
Set the alarm to remind you when it’s time to take a break if necessary. Make sure to leave your workspace at those times. When you return to work, you’ll notice that you’re much more productive than you would have been if you hadn’t taken the break.
Takeaway
The holidays are a splendid time to relax and unwind from work, but thanks to the flexibility of remote work, more extended and more blended vacations are now possible. Set boundaries for yourself and your team, and schedule time away from your laptop, phone, or tablet to spend with family and friends.
We hope that remote work allows you to spend more time with your family this holiday season because the holidays are a time to spend real Facetime with loved ones.
5 thoughts on “Maximize Remote Work Efficiency During the Holidays”
A well-designed powerlifting program is not just about lifting heavy weights; it’s about optimizing
performance, constructing a balanced physique,
and guaranteeing constant progress. The key components
of an efficient powerlifting program embrace understanding
the significance of powerlifting phases, splits,
and periodization. Other considerations are embracing progressive overload and getting rest
for your bodily health and neurological well being.
Tracking progress and measuring energy features in powerlifting requires a systematic approach.
First and foremost, it is important to have a written plan, including the specific workouts, sets, reps, and weights used.
This consistent documentation allows you to observe your progress over time and establish areas where you’ve got made significant gains
or where enhancements are needed. The key to implementing
progressive overload successfully is thru gradual,
managed will increase in resistance.
While pre-designed applications could be effective,
they might not all the time meet the distinctive needs of experienced lifters, probably resulting in turn out to
be stagnant. Creating a well-structured powerlifting training program is important for
long-term progress and peak efficiency. It usually
includes various coaching phases and splits to address totally different features of energy development.
The block might accommodate newer lifters, whereas veteran lifters may acquire advantage from
undulating periodization. Regardless, periodization is a vital device
for powerlifters to make sure they peak on the right time,
break by way of plateaus, and continue making progress.
Constructing a customized program starts with a comprehensive needs assessment.
This includes figuring out an athlete’s strengths and weaknesses by way
of specific lifts.
That’s not a flaw in the programming, you simply need to assume about whether it
aligns along with your goals. I love how all of these beginner energy coaching packages use
full-body exercises. We’d need one thing like a chin-up to deliver in the upper again and biceps.
But assuming you’re using the plugin that provides in chin-ups, these are bonafide full-body workouts.
And regardless, all of those workouts engage no less than many of the muscle tissue
in our bodies.
Arguably the most-advanced of the newbie routines, John Shaeffer’s Greyskull LP takes it one step further than ICF by including AMRAP sets.
This stands for “as many repetitions as possible” and is a technique
used to supply extreme overload in a managed
method. By including AMRAP units, beginners are capable of completely maximize their results each and every week.
Phase your applications to focus primarily on one high quality at a
time as a substitute of a hodgepodge of stuff mashed collectively.
Getting stronger also lowers resting blood pressure and blood cholesterol
ranges, reducing the risk of cardiovascular disease.
There are many examples of very strong, very
muscular people who use very different coaching splits.
[11,12] It doesn’t seem that one type of training split rises above
the rest. We consider our Programs an excellent Do-It-Yourself
(DIY) strategy for getting high-quality programing in your
goals & preferences at an unbeatable price.
A “peaking program” is any program that ends with tapering down quantity and significantly rising intensity in preparation for a powerlifting meet.
The main variables manipulated in a powerlifting program are
frequency, depth, and quantity. That’s as a result of not solely has full body coaching
been shown to be persistently efficient, it’s additionally time environment friendly.
5 of the six coaching routines highlighted on this article call for just three training days per week.
Two of the preferred 6-day exercise splits embrace the
upper/lower and push/pull/legs split. A 6-day workout split could
be very effective for constructing muscle, gaining strength,
and losing fats, so long as it’s programmed well.
With properly periodized powerbuilding programming and scientifically based manipulation of load, depth, frequency, and quantity, we will break via these plateaus.
To sculpt their muscle tissue properly bodybuilders will perform many isolation workout routines (single joint exercises)
at a wide range of angles. Bodybuilders additionally employ training
methods corresponding to drop sets, compound units, compelled reps and training to failure.
Push Pull Legs (PPL) packages are a popular approach to structure bodybuilding,
energy coaching, or powerbuilding fashion programming.
I want to use a training 1-rep max as a end result of I wish
to be sure the quantity is low sufficient to provide an acceptable quantity to start with
on this powerlifting training program. Usually, trainees start too
heavy on a program which leaves them nowhere to go.
That being, you’re not straining so hard you are popping blood vessels; you’re merely in search of an approximate number.
A powerlifting coaching program consists of lifting maximal weight across three totally different movements.
Collectively, these actions are often known as “The Massive Three” in a powerlifting program.
This basic barbell raise tests your energy from head to toe with an emphasis on your back, glutes, and grip.
Under is a quick instruction for the train, however you’ll
have the ability to read much more in our information on tips on how to squat.
Don’t mistake the simplicity of this program for a scarcity of effectiveness.
Maintain this technique of progressive overload up so
long as you probably can. The workouts might be really
brief in the beginning, maybe just 15–20 minutes, and
that’s OK.
So strength training does stimulate some muscle growth, and if enough sets are carried out, it can even stimulate the same
quantity of muscle progress. However the exercises also take longer and are more durable on your body, which isn’t just
inefficient, it also comes with a big alternative value.
As for the muscular stability of the GreySkull program, it’s
rooted in powerlifting culture, and so it’s all in regards to
the hips, quads, entrance delts, chest, and shorter heads of the triceps.
The bigger you build those muscular tissues, the extra you’ll have the
flexibility to squat, bench press, and deadlift. Advanced lifters often require specialised coaching methods to challenge
and stimulate additional strength gains.
References:
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References:
injectable steroid cycles, Stan,
Pharmaceutical grade anabolic steroids, whether they’re injectables or oral products often include numerous security checks.
These can embody batch numbers that can be verified with the steroid provider through e-mail or
online and security holograms on merchandise which are tamper proof as seen on Anvarox 15
by Anabolic Phrama. Individuals typically ask us what kind of outcomes they will expect
taking Anavar. It’s necessary to emphasize there is no such factor as a magic pill or a magic bullet when taking fat burners or
prohormones.
Thus, bodybuilders who want to experience the benefits of anavar buy it from the black
market, which is an unlawful apply and should lead to
a nice or jail time. It is the most powerful and well-liked steroid to be
used within the chopping cycle by males or bodybuilders.
It is nicely tolerated and really efficient with no bloating unwanted facet
effects.
The penalties for unlawful drug use are very extreme in the UAE, so it isn’t well
worth the risk. Anavar is a Schedule IV drug in Australia and is
illegal to own or promote with no prescription. Anavar is an illegal drug in the UK and it’s not worth the danger of possessing or supplying it.
There are, however, some companies that manufacture and sell Anavar with no prescription, but it’s important to
notice that these products are not necessarily legal.
First and foremost, get professional recommendation from your physician about which steroid model is best for you and which isn’t.
There aren’t any virilization side effects with Anavar, so it’s in style amongst girls.
Enrolling in a nationwide sports activities group, or perhaps your university’s
staff, will generally provide efficiency enhancement options, together with
Anavar, even with out your solicitation.
There are totally different classes of steroids that may be found in stores, or on-line.
There are injectable steroids, oral steroids, PCT (Post Cycle Therapy) steroids, and non-steroid alternatives.
The commonest for efficiency enhancers are the injectable and oral steroids.
The legality of buying Anavar can range significantly
from one nation to a different. In many places, including the United States and parts
of Europe, Anavar is assessed as a controlled substance, which suggests it could
solely be legally bought with a prescription. Earlier Than making an attempt to purchase Anavar online, ensure you understand the authorized framework in your
area to keep away from potential legal points. These
items usually are not intended for the analysis, therapy, treatment, or prevention of any
disease.
Anavar was initially developed to help sufferers recover weight after medical trauma,
such as surgical procedure or infection. Over time, its benefits for muscle constructing and fat loss captured the eye of bodybuilders and athletes.
For these in search of to buy Anavar from reputable retailers, five dependable sources have been recognized.
Pure Anabolics and Steroid Warehouse each offer high-quality merchandise with rigorous testing for
purity. Muscle Gain Prescription Drugs ensures clear dosage tips and clear enterprise practices.
Offline sources, like native gyms or fitness retailers, allow
for personal interactions however might have restricted availability.
Staying knowledgeable will assist you to keep
away from legal troubles and buy Anavar responsibly. If you may be contemplating making that healthier
switch, you may want to know what Anvarol does in one other way.
Possession of steroids and not using a prescription is considered a criminal offense and may find yourself in fines, imprisonment, and deportation for non-citizens.
Oxandrolone, actually stands out on the planet of performance-enhancing medicine.
To keep away from counterfeits, you must only purchase Anavar within the
UK from a good seller who is ready to confirm the product’s authenticity.
Analysis the seller totally and read customer reviews before putting your order.
If you are in search of prime quality Anavar, you will need to put some time and effort into your search.
You shouldn’t make a buy order on the idea of the product
being supplied, however somewhat hunt down unbiased reviews on the brand and
provider in question. Failure to do so will greater than doubtless result in an inferior
product.
Anavar 50 is a man-made steroid, just like the typically created hormone testosterone in the human body.
However, some athletes have contraindications to the use of testosterone-containing AAS, and in this scenario, Anavar is the one drug that
can help enhance athletic efficiency. The lively substance Oxandrolone is an oral steroid that has lowered androgenic exercise and elevated anabolic activity.
The drug has been actively used in medication to stimulate linear progress
processes in kids, as properly as in the remedy
of osteoporosis in women. But quite rapidly, Oxandrolone was
observed by athletes who began utilizing the steroid to
extend endurance. Also, to unravel an identical
drawback, the drug can be used in these strength disciplines in which athletes want to stay inside their weight
category. You have come to the proper place, on this article, we’ll let you know every thing about this steroid and reply your questions.
If you want to purchase Anavar in Mexico, you’ll be happy
to know that it’s broadly obtainable for sale in the country.
Anavar is a managed substance in Mexico, which signifies that it could solely be obtained with a prescription from a licensed medical practitioner.
There are loads of other methods to train and put together for a boxing
match that don’t involve illegal medication. While Anavar might provide you
with an edge within the ring, it’s not value risking your well being
and profession for. Although Anavar is not technically a banned substance in Turkey, it is illegal
to own and promote without a prescription. Analyzing steroids like this one is very harsh on liver features and can trigger long-term injury.
We’ll train you tips on how to choose probably the most acceptable provider for you
and also give you a 10% discount code from one of our lately verified suppliers.
Regardless of your circumstance, we are here that can assist you decipher the
confusion of the world wide web and share our prime tips for purchasing
Anavar on-line. Have spent appreciable time and money on “legal alternatives” with related names without seeing any results.
In right now’s fast-paced world, keeping up with daily demands may be exhausting.
We often battle to steadiness work, private life, and well being,
which leads to decreased vitality and stamina.
The solo cycle of Anavar lasts for 6-8 weeks and the dosage varies from 40mg to 80mg taken orally as soon as per day.
Both women and men can use the drug, the dosage for girls is 10-20mg per day.
These who are thinking about higher dosage can find Anavar 50mg on the market from one other trusted website.
In distinction, when buying unlawful anavar (oxandrolone) there’s
always a danger that it won’t be the true factor. The
only method to safeguard towards this is to ask for a pattern, then to carry out a take
a look at for the precise substance and the purity.
References:
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Nettle leaf extract has been shown to bind with sex hormone-binding globulin (SHBG), a
protein that may bind to testosterone and render it inactive.
By lowering the binding of testosterone to SHBG,
nettle leaf extract helps improve the levels of free testosterone within the physique.
This elevation in testosterone levels can potentially improve muscle growth and enhance athletic efficiency.
Any new steroid regimen ought to always be approached gradually,
so as to not subject your self to excessive unforeseen results.
The above cycles should be thought-about as considerably typical,
but not as beginning points. If you are making an attempt trenbolone for the primary time, you could wish to try trenbolone acetate
first, as it’ll clear your system fastest, in the event of extreme unwanted effects.
Proviron can be a weak Anti Estrogenic compound, and has a tendency to provide you a drier and extra full look.
As A End Result Of Tren shifts water from outside the muscle and relocates it INSIDE the muscle cell, your muscle tone and definition will enhance A LOT.
If you utilize Trenbolone whilst bulking you’re going to have ridiculous gains.
TREN-MAX is meant to be a authorized alternative to perhaps the preferred steroid on the earth – Trenbolone.
It needs to be stated that this won’t come close to the outcomes of Trenbolone, however,
it won’t have any of the unwanted side effects. It additionally
means they have completely different length esters, thus positive aspects will come by
faster/slower relying on which one you take.
When it involves muscle building, Trenbolone Enanthate is a best choice among bodybuilders and athletes.
This injectable steroid is renowned for its capacity to promote important muscle growth and energy achieve.
Indeed, many alternatives are available should you’re on the lookout for the benefits
Trenbolone usually provides. This legal and side-effect-free substance helps to facilitate increased
muscle growth and energy, permitting you to attain your
targets risk-free.
By adhering to security protocols, sustaining a balanced
lifestyle, and prioritizing correct restoration, users can obtain sustainable
results whereas safeguarding their well-being. Trenbolone’s
transformative effects are finest realized
when approached with self-discipline, knowledge, and a dedication to security.
For those prepared to put in the effort, Trenbolone
could be a highly effective ally in achieving
their fitness aspirations. Cortisol, the body’s main stress hormone,
can have a catabolic effect, breaking down muscle tissue and inhibiting
development. Trenbolone helps reduce cortisol levels,
creating a extra favorable surroundings for muscle preservation and development.
This profit is very essential during periods of intense coaching or
calorie deficits, where cortisol ranges are inclined to rise.
The combination of fat loss and lack of subcutaneous water provides you with that lean look.
Holding on to it after the cycle presents a greater challenge than attaining your shredded physique through the cycle, and this is one thing
you must plan for. There’s rather more to know concerning the unwanted effects of Anavar and all anabolic steroids, so go to my primary unwanted facet effects guide here.
Anavar will suppress your testosterone at just about any dosage, and the higher the dose, the extra suppression you presumably
can anticipate. The Hypothalamic Pituitary Testicular Axis (HPTA) can doubtlessly turn out
to be damaged with extreme steroid use, presumably inflicting permanent
damage to your testosterone production in excessive
instances. Once once more, Anavar is taken into account comparatively mild on the liver in contrast with other oral steroids because it passes through the
liver faster.
In addition, the results showed that trenbolone acetate also promoted larger satellite tv for
pc cell activation and growth in skeletal muscular tissues.
This research may have a major impression on the way that athletes
are handled, as properly as offering valuable info for many who want to enhance their muscle mass.
If this pattern continues, it is probably that we’re going to see increasingly
athletes turning to trenbolone acetate as their go-to substance for muscle
growth and energy enhancement. Trenbolone acetate is a popular ester pro-drug of trenbolone, an artificial anabolic steroid
that’s estimated to be three to five times stronger than testosterone on the androgen receptor [1].
Some users will endure from extreme cramping, but
others will have zero issues with cramps. Increasing your intake (or
supplementing) of meals wealthy in potassium and magnesium can go an extended approach to decreasing
muscle cramps. Some users will find drastic ldl cholesterol changes of their
bloodwork, while others are nearly untouched. Diet will play a job, as
will dosage, but the one method to actually know what Tbol is doing
to your lipids is to undertake that necessary, common bloodwork.
Regardless Of its mildness, Tbol will always trigger testosterone suppression, and
PCT is required after using this steroid. A widespread mistake is
pondering that low libido, despair, and low energy are attributable to low testosterone when utilizing Tbol.
In some circumstances, you possibly can take steps to scale back
and even forestall a few of these short-term unwanted aspect effects,
such as anti-estrogen medicine. Thankfully, unlike plenty of different
PEDs, the possibility of buying bunk, low-purity Testosterone Enanthate is uncertain because of this being a steroid in massive supply in pharmaceutical
grade. So, the chance of surprising side effects as a end
result of bunk gear is extraordinarily low with Testosterone
Enanthate.
This was created for the advantage of those using testosterone
for medical reasons however can additionally be
extremely handy AND appealing for us bodybuilders who would like not to be doing day by day injections.
All steroids include some negatives, but Anavar is on the decrease finish of the scale when it comes to side effects and dangers.
Most of those will solely be of concern if you’re utilizing doses that are too high or utilizing the drug for longer than recommended
intervals.
Quite A Few anabolic steroids have unfavourable traits, similar to high aromatisation levels.
Trenbolone, in contrast, does not achieve this,
which is considered one of its advantages. Oestrogen encourages the growth of fat cells,
which results in greater male breasts and extra
physique fats.
References:
steroid replacement supplements; Stormy,
La mayoría de los esteroides utilizados ilegalmente provienen de contrabando de
otros países, son sacados ilegalmente de las
farmacias estadounidenses, o son sintetizados en laboratorios
clandestinos. Los esteroides anabólicos cambian el cerebro y conducen a la persona a un estado
de gran desgaste psicosocial. El nivel de agresividad revierte en el
entorno y los deja atrapados en estados mentales marcados por el sufrimiento
y la indefensión. De la misma manera, quienes consumieron esteroides anabólicos durante más de 10 años evidenciaron una clara dependencia a estas sustancias.
De esta manera, si cogiéramos a uno de estos chicos y le hiciéramos una resonancia magnética cerebral,
tras diez años de consumo regular de esteroides anabólicos, nos
asustaríamos. Un análisis publicado en la revista científica
Biological Psychiatry nos ofrece datos muy relevantes.
Todos recordamos el nombre de algún atleta que truncó su carrera a causa de estas sustancias.
Los esteroides anabólicos permiten aumentar el volumen de la masa muscular
al alto precio de contraer todo tipo de trastornos en la salud.
Los esteroides anabólicos son suplementos que estimulan las características sexuales masculinas, la musculatura y el deseo
sexual debido a un aumento de la concentración de la hormona testosterona.
Hoy día, los esteroides anabólicos aún se siguen utilizando como suplemento para
aumentar masa muscular. ➡️ En estudios posteriores, este mismo
grupo de investigación trató de averiguar la relación dosis-respuesta de la testosterona en hombres jóvenes sanos, analizando los efectos de 25, 50, one hundred twenty five,
300 y 600 mg de enantato de testosterona a la semana sobre la composición corporal.
Al comprender estos elementos clave, estarás mejor preparado para tomar decisiones informadas y seguras si estás considerando incorporar la trembolona en tu régimen de entrenamiento y suplementación. Independientemente del
propósito de su uso, todos aquellos que complementan con Anavar encontrarán que su tasa de
recuperación mejora así como su resistencia muscular.
Esto no significa que debamos aumentar la duración de nuestras sesiones de
entrenamiento, que puede o no ser el caso dependiendo de la situación.
Sin embargo, haremos un mejor uso de cada sesión de capacitación, haremos un mejor
uso de nuestro tiempo en el campo y en common se realizará un trabajo de mayor calidad.
La erección es un fenómeno neurovascular
bajo control hormonal, en el que intervienen neurotransmisores,
factores endocrinos, así como agentes vasoactivos, y precisa de la integridad de las propiedades fibroelásticas del tejido cavernoso.
Sigue siendo debatido el papel de los andrógenos en la función eréctil (las evidencias existentes sobre la influencia
de la testosterona en la función eréctil son sobre todo a nivel experimental).
Los andrógenos intervendrían en la regulación bioquímica del
proceso fisiológico de la erección, su déficit parece provocar cambios estructurales en el tejido cavernoso que afectan especialmente a la activación y al
mantenimiento del mecanismo venooclusivo.
Así, en estudios experimentales en ratas, se
ha demostrado que la privación de andrógenos por castración altera la ultraestructura de los nervios cavernosos, del nervio dorsal del pene y puede
producir fuga venosa29,30, alteraciones reversibles tras el tratamiento con testosterona31.
También se ha comprobado que la erección producida por estimulación del área medial preóptica en ratas es dependiente de la testosterona33.
Por tanto, los andrógenos parecen common en el animal de experimentación los mecanismos neurológicos
de la erección, tanto a nivel central como periférico.
Otros estudios experimentales en ratas han demostrado que
la testosterona regula la expresión y la actividad de
las distintas isoformas (neuronal y endotelial) de la sintasa
de óxido nítrico (NOS) en el cuerpo cavernoso34,35.
El abuso de los esteroides se ha difundido a tal extremo
en el atletismo, que afecta el resultado
de las competencias deportivas. Las hormonas esteroideas
trabajan por estimulación de moléculas receptoras en las
células musculares, quienes afectan genes específicos para producir proteínas (Figura
1). También afectan la tasa de activación de los sistemas enzimáticos
involucrados en el metabolismo proteico, por esta razón incrementan la síntesis proteica e inhiben la proteolisis (llamado efecto
anti-catabólico). Pueden ser consumidos en diferentes formatos, en pastilla, aplicado en gel o crema o
inyectado directamente en el músculo. Por norma common, los esteroides anabólicos cuentan con fluoximesterona y nandrolona.
Ellos también dicen que tienen dificultades para realizar progresos cuando no ingieren estas sustancias.
Los anabólicos esteroides pueden tener efectos anticatabólicos, lo que significa que estas drogas previenen contra el catabolismo
muscular que generalmente acompaña al entrenamiento intenso.
Se suelen usar para tratar diferentes afecciones hormonales
como el retraso en la pubertad.
Los corticoides se utilizan para tratar la artritis reumatoide, la enfermedad inflamatoria
intestinal, el asma, las alergias y muchas otras afecciones.
También se usan para prevenir el rechazo
de órganos en receptores de trasplantes, ya que ayudan a inhibir el sistema inmunitario.
Esta es una enfermedad poco frecuente que se produce cuando las glándulas suprarrenales
no generan la cantidad suficiente de corticoide que el cuerpo
necesita. El motivo es, en parte, que alteran los niveles de
colesterol en sangre, aumentando las lipoproteínas de baja densidad (el colesterol malo) y disminuyendo las de alta densidad (el colesterol
bueno). Esto aumenta el riesgo de arteriosclerosis, una patología
en la que las moléculas de grasa se acumulan en las arterias dificultando el flujo
sanguíneo en forma de bloqueos y coágulos.
La falta de 5α-reductasa en el testículo, podría explicar por qué los inhibidores de esta enzima no tienen un marcado efecto en la espermatogénesis22; por consiguiente, la testosterona no
es reducida a DHT. Esta es más potente ligada al RA que aquella,
por lo que en el compartimiento tubular, en ausencia de DHT y para mantener la expresión del RA, será necesario mantener
niveles altos de testosterona que se encontrará principalmente ligada a la ABP producida por las células de Sertoli23.
Los túbulos seminíferos están expuestos a concentraciones
de testosterona de 25 a a hundred veces mayor que los niveles circulantes.
En resumen, los esteroides son pilar importante
en el tratamiento de diferentes enfermedades inflamatorias,
autoinmunes e infecciosas, tanto sistémicas como
oculares. A pesar de su efectividad, su uso puede venir acompañado de efectos secundarios, como el
glaucoma inducido por esteroides, la formación de cataratas,
el retraso en la cicatrización de heridas y el empeoramiento de infecciones.
Por eso, se sugiere que los médicos no
oftalmólogos consideren referir a cualquier paciente en tratamiento prolongado con esteroides sistémicos a un médico oftalmólogo, para que evalúe
la posible aparición de glaucoma y cataratas.
Pues bien, en el transcurso de 8 semanas el grupo que se le
administró nandrolona en combinación con el
entrenamiento de fuerza, ganó 2,6 kg de masa muscular, mientras que
el grupo que recibió un placebo solo ganó 0,8 kg. Pero esta no es la única prueba de la magnitud
y del efecto de los esteroides en la ganancia de masa muscular.
Por definición, los esteroides son un grupo de sustancias de estructura
policíclica de 17 átomos de carbono de la que derivan compuestos de gran importancia biológica, tales como los ácidos
biliares y algunas hormonas.
La testosterona no parece actuar directamente
en las células germinales, sino funcionando a través de las células de Sertoli por expresión del RA e influyendo en el microambiente tubular.
Puede metabolizarse a estradiol por acción de la estrógeno sintetasa o aromatasa,
presente en el testículo. En el varón también hay actividad aromatasa en la próstata, cerebro, adipocitos, fibroblastos de la piel,
hueso y en las células del estroma del pecho24, siendo
regular una producción diaria de 50 μg.
Aunque el papel del estrógeno en el compartimiento tubular no es
bien conocido, se ha indicado un efecto
estrogénico en la secreción de inhibina B por
las células de Sertoli. También es possible que la acción estrogénica sea importante para el desarrollo celular
y función de las células de Leydig, de Sertoli y germinales25.
Las personas que dejan de tomar esteroides también se encuentran con menores cantidades de hormona masculina que
en lo ordinary, durante los períodos sin consumos de esteroides.
Los efectos catabólicos del cortisol se incrementan cuando los atletas dejan de tomar drogas mientras que
la fuerza y el tamaño muscular se pierden en una alta tasa.
References:
theyellowdogproject.com